Research Article
Association between Polymorphisms of Antioxidant Gene (MnSOD, CAT, and GPx1) and Risk of Coronary Artery Disease
Table 4
Association between MnSOD, CAT, and GPx1 genotypes and risk of coronary artery disease stratified by cigarette smoking status.
| | Genotype | Cigarette smokinga | Cases, n (%) | Controls, n (%) | OR(95%CI)b | P-value |
| | MnSOD | | | | | | | Val/Val | Never | 150(33.6) | 109(51.9) | 1.00 | | | Val/Ala+Ala/Ala | Never | 44(9.9) | 20(9.5) | 1.79(0.95-3.37) | 0.073 | | Val/Val | Ever | 201(45.1) | 72(34.3) | 1.00 | | | Val/Ala+Ala/Ala | Ever | 51(11.4) | 9(4.3) | 2.23(1.02-4.88) | 0.045 | | P for interaction | | | 0.552 | | | CAT | | | | | | | C/C | Never | 174(39.0) | 122(58.1) | 1.00 | | | C/T+T/T | Never | 20(4.5) | 7(3.3) | 1.80(0.71-4.60) | 0.217 | | C/C | Ever | 228(51.1) | 75(35.7) | 1.00 | | | C/T+T/T | Ever | 24(5.4) | 6(2.9) | 1.20(0.46-3.12) | 0.708 | | P for interaction | | | 0.387 | | | GPx1 | | | | | | | Pro/Pro | Never | 177(39.7) | 116(55.2) | 1.00 | | | Pro/Leu | Never | 17(3.8) | 13(6.2) | 1.06(0.47-2.41) | 0.894 | | Pro/Pro | Ever | 228(51.1) | 75(35.7) | 1.00 | | | Pro/Leu | Ever | 24(5.4) | 6(2.9) | 1.23(0.47-3.21) | 0.674 | | P for interaction | | | 0.773 | |
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a: “Never” is nonsmokers and “Ever” is the combination of current smokers and ex-smokers.
b: adjusted for age, sex, and alcohol drinking.
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