Differential Expression of IL-36 Family Members and IL-38 by Immune and Nonimmune Cells in Patients with Active Inflammatory Bowel Disease

Figure 2

IL-36 expression in immune and nonimmune intestinal cells from IBD patients. (a) CD14⁺/IL-36α expressing cells and (b) CD123⁺/IL-36α pDCs. Representative immunoperoxidase in tissue from active UC patients (n=10; left panel), active CD patients (n=10; middle panel), and noninflamed colonic tissue (n=10; right panel). Photomicrographs represent mucosa, submucosa, muscular, and serosa. Dotted arrows depict the cytokine expression, solid arrows show expression of cell-surface marker (leukocytes), double arrows indicate CD14⁺ or CD123⁺ (in brown)/IL-36α (in pink) double positive cells (burgundy), and circles highlight the immunoreactive perivascular inflammatory infiltrates. Original magnification was X320.

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(b)