Suppression of Th1 and Th17 Responses and Induction of Treg Responses by IL-18-Expressing Plasmid Gene Combined with IL-4 on Collagen-Induced Arthritis
Effect of various vectors on expression of TLRs and their pathways on DCs of spleen and lymph nodes. (a) Representative results showing changes in the expression of TLR2, TLR4, MyD88, NF-κB, TLR9, and TRIF in spleen DCs, determined by real-time PCR analysis at 60 days after immunization. (b) Changes in the expression of TLR2, TLR9, MyD88, NF-κB, TLR4, and TRIF in lymph node DCs were determined by real-time PCR. versus control by Student’s -test; versus control by Student’s -test.