Blockade of RBP-J-Mediated Notch Signaling Pathway Exacerbates Cardiac Remodeling after Infarction by Increasing Apoptosis in Mice

Figure 2

Higher collagen density in the infarct area in the Myh6-RBP- mice following MI. (a) 25 visual fields at the border zone were randomly selected from 4 mice for each group, and the cross-sectional area of cardiomyocytes was estimated (, and ). Data are shown as means ± SD. (b) 4 weeks after operation, the hearts of Myh6-RBP--MI mice, RBP--MI mice, Myh6-RBP--sham mice, and RBP--sham mice were sectioned and stained using Masson staining. Cardiac fibrosis was assessed by calculating the ratio of fibrotic scar (blue) average circumferences to left ventricular average inner circumferences (, ). Data are shown as means ± SD.

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