Research Article

Identification of Key Candidate Proteins and Pathways Associated with Temozolomide Resistance in Glioblastoma Based on Subcellular Proteomics and Bioinformatical Analysis

Table 2

Signaling pathway enrichment analyses of down- and upregulated DEPs.

Pathway IDNameCount value

Upregulated
 ko04810Regulation of actin cytoskeleton6
 ko05410Hypertrophic cardiomyopathy (HCM)3
 ko05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)3
 ko04512ECM-receptor interaction3
 ko05414Dilated cardiomyopathy3
 ko05200Pathways in cancer6
 ko05205Proteoglycans in cancer5
 ko04151PI3K-Akt signaling pathway5
 ko04380Osteoclast differentiation3
 ko05032Morphine addiction2
 ko04640Hematopoietic cell lineage2
 ko04919Thyroid hormone signaling pathway3
 ko05020Prion diseases2
 ko04727GABAergic synapse2
 ko04728Dopaminergic synapse3
 ko04145Phagosome4
 ko00361Chlorocyclohexane and chlorobenzene degradation1
 ko00364Fluorobenzoate degradation1
 ko00623Toluene degradation1
 ko04510Focal adhesion4
 ko05100Bacterial invasion of epithelial cells3
 ko04723Retrograde endocannabinoid signaling2
 ko04713Circadian entrainment2
 ko04130SNARE interactions in vesicular transport2
 ko05140Leishmaniasis2
 ko04724Glutamatergic synapse2
 ko04115p53 signaling pathway2
 ko04514Cell adhesion molecules (CAMs)2
 ko05133Pertussis2
 ko05222Small cell lung cancer2
 ko04726Serotonergic synapse2
 ko04725Cholinergic synapse2
 ko04211Longevity regulating pathway, mammal2
 ko05134Legionellosis2
Downregulated
 ko03010Ribosome13
 ko03008Ribosome biogenesis in eukaryotes3
 ko03013RNA transport5