Role of the Death Receptor and Endoplasmic Reticulum Stress Signaling Pathways in Polyphyllin I-Regulated Apoptosis of Human Hepatocellular Carcinoma HepG2 Cells

Figure 1

Effects of PPI on the viability of HepG2 cells. Chemical structure of polyphyllin I (a). HepG2 cells were incubated with various concentrations of PPI for 6, 12, and 24 h. Relative cell viability was determined via a Cell Counting Kit-8 assay (b). Cell morphology was observed via microscopy following treatment with PPI at 0-5 μM for 12 h (c). Data were obtained from three independent experiments. p < 0.05 and p < 0.01, vs. the control group (0μM). PPI, polyphyllin I.

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