Effect of Polyvalence on the Antibacterial Activity of a Synthetic Peptide Derived from Bovine Lactoferricin against Healthcare-Associated Infectious Pathogens

Table 1

Antibacterial peptides derived from LfcinB in this study.

Peptide

Sequence

M+H

Net

Motif

R

W

Q

W

986.7

+3

−3.133

12.30

Palindromic

R

W

Q

W

R

W

Q

W

R

1488.6

+3

−2.678

12.30

LfcinB reference

^17F

K

C

R

R

W

Q

W

R

M

K

K

L

G

A^31

1994.7

+6

−1.207

11.74

Dimeric

(R

R

W

Q

W

R)2

K

Ahx

2198.5

+6

- -

- -

Tetrameric

(R

R

W

Q

W

R)4

K2

Ahx2

C2

4594.6

+12

- -

- -

charge and grand average of hydropathy (GRAVY) were calculated using the Antimicrobial Peptide Calculator and Predictor (http://aps.unmc.edu/AP/prediction/prediction_main.php). pI values were calculated using the Compute pI/Mw Tool (https://web.expasy.org/compute_pi/).