Effect of Polyvalence on the Antibacterial Activity of a Synthetic Peptide Derived from Bovine Lactoferricin against Healthcare-Associated Infectious Pathogens
Table 2
Antibacterial activity of synthetic peptides derived from the LfcinB RRWQWR motif against HCAI pathogens.
Peptide
Staphylococcus aureus
Klebsiella pneumonia
ATCC 25923 Sensitive
ATCC 33591 Resistant
ATCC 13883 Sensitive
ATCC 700603 Resistant
MIC
MBC
MIC
MBC
MIC
MBC
Motif
>197 (200)
>197 (200)
>197 (200)
>197 (200)
>197 (200)
>197 (200)
>197 (200)
>197 (200)
Palindromic
74 (50)
148 (100)
9 (6.25)
74 (50)
74 (50)
148 (100)
74 (50)
148 (100)
LfcinB reference
>398 (200)
>398 (200)
100 (50)
199 (100)
>398 (200)
>398 (200)
>398 (200)
>398 (200)
Dimeric
14 (6.25)
110 (50)
55 (25)
110 (50)
27 (12.5)
55 (25)
27 (12.5)
220 (100)
Tetrameric
29 (6.25)
57 (12.5)
57 (12.5)
57 (12.5)
29 (6.25)
115 (25)
57 (12.5)
115 (25)
minimum inhibitory concentration expressed in µg/mL and (µM). minimum bactericidal concentration expressed in µg/mL and (µM). Data are the averages of four independent experiments, each performed in duplicate.
