Research Article

Computing of Low Shear Stress-Driven Endothelial Gene Network Involved in Early Stages of Atherosclerotic Process

Table 3

List of microRNA and transcription factors added to the regulatory network after the enhancing process. Node represents the regulator’s name, type describes if the regulator is a transcription factor or a microRNA, PMID is the PubMed ID of the reference paper, and Function contains the overall regulatory function.

NodeTypePMIDFunction

HSA-MIR-155External Mirna23512606Angiogenesis
HSA-MIR-18AExternal Mirna21171923Angiogenesis
HSA-MIR-18BExternal Mirna21171923Angiogenesis
HSA-MIR-20BExternal Mirna24158362Angiogenesis
HSA-MIR-22External Mirna23512606Angiogenesis
HSA-MIR-221External Mirna23512606Angiogenesis
HSA-MIR-222External Mirna23512606Angiogenesis
HSA-LET-7A-1External Mirna21171923Apoptosis
HSA-LET-7A-2External Mirna21171923Apoptosis
HSA-LET-7A-3External Mirna21171923Apoptosis
HSA-LET-7GExternal Mirna21171923Apoptosis
HSA-MIR-17External Mirna21171923Apoptosis
HSA-MIR-20AExternal Mirna21171923Apoptosis
HSA-MIR-29B-1External Mirna21171923Apoptosis
HSA-MIR-29B-2External Mirna21171923Apoptosis
HSA-MIR-488External Mirna21710544Apoptosis
HSA-MIR-103A-1External Mirna22267480Atherogenesis
HSA-MIR-103A-2External Mirna22267480Atherogenesis
HSA-MIR-24-1External Mirna23729638Atherogenesis
HSA-MIR-24-2External Mirna23729638Atherogenesis
HSA-MIR-26A-1External Mirna22267480Atherogenesis
HSA-MIR-26A-2External Mirna22267480Atherogenesis
HSA-MIR-31External Mirna23729638Atherogenesis
HSA-MIR-146AExternal Mirna21171923Inflammatory response
HSA-MIR-193BExternal Mirna23729638Inflammatory response
HSA-MIR-206External Mirna23381794Inflammatory response
HSA-MIR-208AExternal Mirna23797034Inflammatory response
HSA-MIR-224External Mirna22178270Inflammatory response
HSA-MIR-302CExternal Mirna21490602Inflammatory response
HSA-MIR-34AExternal Mirna21171923Inflammatory response
HSA-MIR-34CExternal Mirna26779287Inflammatory response
HSA-MIR-378AExternal Mirna25104350Inflammatory response
HSA-MIR-9-1External Mirna23797034Inflammatory response
HSA-MIR-9-2External Mirna23797034Inflammatory response
HSA-MIR-9-3External Mirna23797034Inflammatory response
HSA-MIR-98External Mirna25623956Inflammatory response
HSA-MIR-19AExternal Mirna22047531NO synthesis and response
HSA-MIR-200BExternal Mirna23975169NO synthesis and response
HSA-MIR-21External Mirna22047531NO synthesis and response
HSA-MIR-127External Mirna24282530Senescence
HSA-MIR-34BExternal Mirna20424141Senescence
HSA-MIR-145External Mirna23512606Shear stress regulation
HSA-MIR-19B-1External Mirna25012134Shear stress regulation
HSA-MIR-19B-2External Mirna25012134Shear stress regulation
ARTranscription Factor26097556Inflammatory response
CREB1Transcription Factor25883219Inflammatory response
ESR1Transcription Factor26808832Inflammatory response
FOXA1Transcription Factor24801505Inflammatory response
FOXP3Transcription Factor21873519Inflammatory response
IRF1Transcription Factor23934855Inflammatory response
IRF2Transcription Factor2475256Inflammatory response
YBX1Transcription Factor23872051Inflammatory response
ETS1Transcription Factor18636553Shear stress regulation
GATA1Transcription Factor15231498Shear stress regulation
GATA2Transcription Factor15231498Shear stress regulation
GATA3Transcription Factor15231498Shear stress regulation
MYCTranscription Factor9598824Shear stress regulation
PAX5Transcription Factor19616560Shear stress regulation