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BioMed Research International
Volume 2018, Article ID 5362948, 8 pages
Research Article

Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study

1Department of Epidemiology and Public Health, University College London, London, UK
2Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden
3Department of Health and Social Behavior, School of Public Health, University of Tokyo, Tokyo, Japan
4Division of International and Community Oral Health, Graduate School of Dentistry, Tohoku University, Miyagi, Japan
5Department of Statistics, Örebro University, Örebro, Sweden
6Center for Preventive Medical Science, Chiba University, Chiba, Japan

Correspondence should be addressed to N. Cable;

Received 13 September 2017; Revised 6 December 2017; Accepted 18 December 2017; Published 22 January 2018

Academic Editor: Rei Shibata

Copyright © 2018 N. Cable et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We examined correlating clinical biomarkers for the physical aspect of frailty among community-dwelling older adults in Japan, using Japanese Gerontological Evaluation Study (JAGES). We used information from the JAGES participants ( = 3,128) who also participated in the community health screening in 2010. We grouped participants’ response to the Study of Osteoporotic Fracture (SOF) Frailty Index into robust (=0), intermediate frail (=1), and frail (=2+) ones to indicate physical aspect of frailty. Independent of sex and age, results from multinomial logistic regression showed above normal albumin and below normal HDL and haemoglobin levels were positively associated with intermediate frail (RRR = 1.99, 95% CI = 1.22–3.23; RRR = 1.36, 95% CI = 1.33–1.39; RRR = 1.36, 95% CI = 1.23–1.51, resp.) and frail cases (RRR = 2.27, 95% CI = 1.91–2.70; RRR = 1.59, 95% CI = 1.51–1.68; RRR = 1.40, 95% CI = 1.28–1.52, resp.). Limited to women, above normal Hb1Ac level was similarly associated with intermediate frail and frail cases (RRR = 1.18, 95% CI = 1.02, 1.38; RRR = 2.56, 95% CI = 2.23–2.95, resp.). Use of relevant clinical biomarkers can help in assessment of older adults’ physical aspect of frailty.