Research Article

Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study

Table 1

Sample characteristics, numbers of participants, and proportions (%) by levels (below normal, normal, and above normal) of study biomarkers according to the SOF Frailty category ().

SOF Frailty Index category
RobustIntermediateFrail
()()()

Frequency (row%)
Demographic
Age in year, mean (SD)70.9 (4.8)71.7 (5.3)73.6 (6.4)
Gender
 Men732 (49.1)609 (40.8)151 (10.1)
 Women702 (42.9)671 (41.0)263 (16.1)
Biomarkers (units)
HbA1c (%): men
 Below normal81 (53.6)53 (35.1)17 (11.3)
 Normal527 (48.3)454 (41.7)109 (10.0)
 Above normal121 (48.8)101 (40.7)26 (10.5)
HbA1c (%): women
 Below normal120 (40.4)131 (44.1)46 (15.5)
 Normal532 (44.8)482 (40.6)174 (14.6)
 Above normal53 (34.4)59 (38.3)42 (27.3)
HDL (mg/dL)
 Below normal147 (38.3)174 (45.3)63 (16.4)
 Normal1255 (46.7)1087 (40.4)347 (12.9)
 Above normal32 (58.2)19 (34.5)4 (7.3)
LDL (mg/dL)
 Below normal25 (45.5)16 (29.1)14 (25.5)
 Normal1306 (45.7)1172 (41.1)377 (13.2)
 Above normal103 (47.2)92 (42.2)23 (10.6)
Triglyceride (mg/dL)
 Below normal5 (35.7)8 (57.1)1 (7.1)
 Normal1023 (46.4)883 (40.1)297 (13.5)
 Above normal406 (44.6)389 (42.7)116 (12.7)
Haemoglobin (g/dL)
 Below normal259 (38.3)297 (43.9)120 (17.8)
 Normal1118 (48.0)935 (40.1)277 (11.9)
 Above normal57 (46.7)48 (39.3)17 (13.9)
Serum albumin (g/dL)
 Below normal89 (36.0)89 (36.0)69 (27.9)
 Normal1335 (46.8)1176 (41.2)341 (12.0)
 Above normal10 (34.5)15 (51.7)4 (13.8)
Creatinine (mg/dL)
 Below normal34 (43.6)34 (43.6)10 (12.8)
 Normal1273 (46.3)1117 (40.6)362 (13.2)
 Above normal127 (42.6)129 (43.3)42 (14.1)
Uric acid (mg/dL)
 Below normal27 (45.0)25 (41.7)8 (13.3)
 Normal1252 (46.0)1120 (41.1)352 (12.9)
 Above normal155 (45.1)135 (39.2)54 (15.7)
Urine
 Protein absence1213 (45.9)1083 (41.0)344 (13.0)
 Protein: trace or positive221 (45.3)197 (40.4)70 (14.3)
eGFR (mL/min/1.73 m2)
 Normal1120 (47.0)963 (40.4)300 (12.6)
 Above normal314 (42.1)317 (42.6)114 (15.3)