Do MicroRNAs Modulate Visceral Pain?

Table 1

Involvement of miRNAs in visceral pain.

Diseases	miRNAs	Tissues	Targets	References
IBS	miR-199 ↓	Human colon; Rat colon/DRG	TRPV1 ↑	[60]
	miR-24 ↑	Human/mouse intestinal mucosa	SERT ↓	[61]
	miR-17-5p ↑	Lumbar spinal cord	STAT3↓; gp130↑	[62]
	miR-150 ↑; miR-342-3p ↑	Human whole blood	-	[63]
	miR-29a ↑	Human small bowel and colon; human blood macrovesicles	Glutamate ammonia; ligase ↓	[64]
	miR-144 ↑	Rat distal colonic epithelial cells	Occludin ↓; ZO1 ↓	[65]
Endometriosis	miR-9 ↓; miR-34 ↓	Human endometrial tissues	-	[66]
	miR-142-3p ↑	Endometrial stroma cells	Steroid sulfatase ↓; gp130 ↓	[67]
	miR-29 ↑; miR-181 ↑; let-7 ↑	ox-LDL treated human endometrial cell-lines	NGF ↑; IL-6 ↑; PTGES3 ↑	[68]
	miR-122 ↑; miR-199a ↑	Serum; peritoneal fluid	-	[69]
BPS/IC	miR-449b ↑; miR-500 ↑	Bladder smooth muscle cells	NK1 receptor↓	[70]
	miR-199a-5p ↑	Bladder smooth muscle; Mature bladder urothelium; Primary urothelial culture	LIN7C ↓; ARHGAP12 ↓; PALS1 ↓; RND1↓; PVRL1 ↓	[71]
	miR-214 ↓	Postmenopausal women’s bladder tissue; Ovariectomized rats’ APMSCs	Mfn2 ↑;	[72]
	miR-139-5p ↓	Postmenopausal women’s bladder tissue	LPAR4 ↑	[73]
	miR-181a ↑	Rat spinal cord	↓	[74]
	miR-92b-3p ↑	Rat spinal cord	KCC2↓; VGAT ↓	[75]