Cytogenomic Integrative Network Analysis of the Critical Region Associated with Wolf-Hirschhorn Syndrome

Figure 3

Smallest region of overlapping (SRO) associated with microcephaly and seizures. Bars show deletion sizes and genomic position on 4p. Red horizontal bars indicate seizures and microcephaly phenotype; green bars indicate absence of seizures and microcephaly, and two bars in gray represent critical regions of Wolf-Hirschhorn syndrome (WHS). The smallest region of susceptibility to microcephaly and seizures shown in this study is represented by blue bar, covering a 330 kb in size (1.8 to 2.13 Mb). WHSCR, Wolf-Hirschhorn syndrome critical region.