Bone Regeneration of Peri-Implant Defects Using a Collagen Membrane as a Carrier for Recombinant Human Bone Morphogenetic Protein-2

Figure 7

Histologic views presenting the results of GBR: (a) BMP group with pins, (b) nonBMP group with pins, (c) BMP group without pins, (d) nonBMP group without pins, and (e) control group. The results for defect resolution were not consistent, as demonstrated by some specimens in both the BMP and nonBMP groups exhibiting complete regeneration and others with remaining peri-implant bone defects. Complete resolution of the dehiscence defects was consistently observed in the histology specimens of the BMP and nonBMP groups using pins, while the positioning of bone-substitute particles was disrupted and bone regeneration did not occur uniformly in the group without pins. In the control sites, the size of the peri-implant defects appeared to be similar to the situation prior to augmentation. Asterisk, newly formed bone; arrow, residual bone-substitute material. Scale bar = 1 mm.

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