Learning on the Fly: The Interplay between Caspases and Cancer

Figure 3

Graphic summary of caspase effects in different subcellular locations during cell migration and metastasis. Caspases are known to regulate the cytoskeleton remodelling elements crucial for migration (such as the microtubule-stabilizing protein tau and actin regulators Aip1, Rab5, and Rac), as well as modulating the stability of focal adhesion complexes. They also modulate the secretion of factors into the ECM that facilitate invasion and migration (MMPs and fibronectin).