Identification of Candidate Biomarkers in Malignant Ascites from Patients with Hepatocellular Carcinoma by iTRAQ-Based Quantitative Proteomic Analysis

Figure 3

KEGG pathways in HCC ascites samples compared to HD. (a) The most significantly enriched KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways are illustrated with bubbles. The Y axis indicated the enrichment factor, which refers to the ratio of the differentially distributed protein number to the total protein number in a certain pathway. The size of bubble indicates mean number of proteins enriched in a given pathway. The color of bubble indicates Q value (adjusted p value). (b) Bar plots represent enriched KEGG pathways associated with upregulated (left) proteins and downregulated (right) differentially distributed proteins. The Y axis indicated average change fold of the implicated proteins.

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