Research Article
Identification of Candidate Biomarkers in Malignant Ascites from Patients with Hepatocellular Carcinoma by iTRAQ-Based Quantitative Proteomic Analysis
Table 1
Top upregulated and downregulated proteins identified by iTRAQ (HCC vs. HD, p<0.05).
| Accession | Description/Gene name (Protein name) | Ratio (HCC/HD) | Score |
| Upregulated proteins |
| B4E1B2 | cDNA FLJ53691 | 1.60 | 4358 | Q6MZU6 | DKFZp686C15213 | 2.21 | 3984 | A2MYE1 | VACWR153(A30 protein) | 1.55 | 493 | A2J1N3 | Rheumatoid factor RF-IP20 | 2.72 | 332 | A8K9J7 | H2B(Histone H2B) | 1.97 | 121 | H6VRF8 | KRT1(Keratin-1) | 1.88 | 110 | B0AZL7 | cDNAFLJ79457(highly similar to Insulin-like growth factor-binding protein) | 1.66 | 62 | A0N8J1 | V(k)3 sequence of NG9 gene from fetal liver DNA | 1.52 | 57 | P35908 | KRT2(Keratin-2) | 1.53 | 51 | Q04756 | HGFA(Hepatocyte growth factor activator) | 1.59 | 45 |
| Downregulated proteins | ā | ā |
| Q6PIQ7 | IGL(Immunoglobulin lambda) | 0.61 | 3129 | Q6DHW4 | Uncharacterized protein | 0.60 | 526 | A0A0J9YXX1 | Uncharacterized protein | 0.43 | 146 | E5RIF9 | CA1(Carbonic anhydrase 1) | 0.57 | 104 | Q5NV65 | V1-5(V1-5 protein) | 0.64 | 45 |
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