Identification of Candidate Biomarkers in Malignant Ascites from Patients with Hepatocellular Carcinoma by iTRAQ-Based Quantitative Proteomic Analysis

Table 1

Top upregulated and downregulated proteins identified by iTRAQ (HCC vs. HD, p<0.05).

Accession	Description/Gene name (Protein name)	Ratio (HCC/HD)	Score
Upregulated proteins
B4E1B2	cDNA FLJ53691	1.60	4358
Q6MZU6	DKFZp686C15213	2.21	3984
A2MYE1	VACWR153(A30 protein)	1.55	493
A2J1N3	Rheumatoid factor RF-IP20	2.72	332
A8K9J7	H2B(Histone H2B)	1.97	121
H6VRF8	KRT1(Keratin-1)	1.88	110
B0AZL7	cDNAFLJ79457(highly similar to Insulin-like growth factor-binding protein)	1.66	62
A0N8J1	V(k)3 sequence of NG9 gene from fetal liver DNA	1.52	57
P35908	KRT2(Keratin-2)	1.53	51
Q04756	HGFA(Hepatocyte growth factor activator)	1.59	45
Downregulated proteins
Q6PIQ7	IGL(Immunoglobulin lambda)	0.61	3129
Q6DHW4	Uncharacterized protein	0.60	526
A0A0J9YXX1	Uncharacterized protein	0.43	146
E5RIF9	CA1(Carbonic anhydrase 1)	0.57	104
Q5NV65	V1-5(V1-5 protein)	0.64	45