Identification of Candidate Biomarkers in Malignant Ascites from Patients with Hepatocellular Carcinoma by iTRAQ-Based Quantitative Proteomic Analysis

Table 2

Top upregulated and downregulated KEGG pathways identified by iTRAQ (HCC vs. HD).

Pathway ID	Pathway Name	Gene Name
Upregulated proteins
ko00010	Glycolysis / Gluconeogenesis (p<0.05)	GAPDH, ENO1,PGK1
ko01200	Carbon metabolism (p<0.05)	GAPDH,ENO1,PGK1
ko01230	Biosynthesis of amino acids (p<0.05)	GAPDH,ENO1,PGK1
ko00710	Carbon fixation in photosynthetic organisms	GAPDH,PGK1
ko04066	HIF-1 signaling pathway	GAPDH,ENO1
ko00680	Methane metabolism	ENO1
ko03018	RNA degradation	ENO1
ko04015	Rap1 signaling pathway	PFN1
ko04080	Neuroactive ligand-receptor interaction	CTSG
ko04142	Lysosome	CTSG
ko04145	Phagosome	MPO
ko04614	Renin-angiotensin system	CTSG
ko04672	Intestinal immune network for IgA production	PIGR
ko04810	Regulation of actin cytoskeleton	PFN1
ko05010	Alzheimer's disease	GAPDH
ko05131	Shigellosis	PFN1
ko05132	Salmonella infection	PFN1
ko05146	Amoebiasis	CTSG
ko05202	Transcriptional misregulation in cancer	MPO
ko05322	Systemic lupus erythematosus	CTSG
Downregulated proteins
ko04610	Complement and coagulation cascades (p<0.10)	CO4B, FIBA, FGB ANT3, PLMN, VTNC A2AP, IPSP, Q8IZZ5
ko04611	Platelet activation	FGA
ko05150	Staphylococcus aureus infection	C4B
ko04080	Neuroactive ligand-receptor interaction	PLG
ko04151	PI3K-Akt signaling pathway	VTNC
ko04510	Focal adhesion	VTNC
ko04512	ECM-receptor interaction	VTNC
ko05133	Pertussis	CO4B
ko05164	Influenza A	PLG
ko05205	Proteoglycans in cancer	VTNC
ko05322	Systemic lupus erythematosus	CO4B