Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary Intervention

Table 4

Meta-analyses comparing outcomes of dual with triple therapy.

Study/author	Year	Patient population	Number of patients	Comparison	Results
Agarwal et al. [8]	2017	Patients with an indication for long-term anticoagulation undergoing PCI	7,276	TT versus DT	(1) Less major bleeding with OAC + SAPT; (2) Comparable outcomes between OAC + SAPT and TT for MACE, MI, stent thrombosis, CV mortality
Liu et al. [46]	2016	Patients with indication for OAC and undergoing PCI or medically managed ACS	22,842	Network meta-analysis of TT, OAC + C, OAC + A, DAPT	(1) OAC + C had the lowest rate of MACE, CVA, MI, all-cause mortality, and major bleeding
Barbieri et al. [47]	2016	Patients undergoing PCI that required long-term OAC	21,716	TT versus DT	(1) As compared to DT, the use of TT was associated with significant reduction in overall mortality, recurrent MI, and ischemic stroke; (2) Patients with TT were found to have a higher incidence of bleeding
D’Ascenzo et al. [48]	2015	Patients with indication for OAC and undergoing PCI or medically managed ACS	7,182	TT versus DAPT, TT versus OAC + C	(1) Major bleeding: DAPT and OAC + C both had less incidence as compared to TT; (2) MACE: no benefit of TT over OAC + C or DAPT
Gao et al. [49]	2015	Patients taking OAC with coronary stent implantation	9,185	TT versus OAC + C	(1) Lower incidence of MACE with OAC + C; (2) Comparable outcomes between OAC + C and TT for all-cause mortality, MI, ST, ischemic thrombosis, and major and minor bleeding

ACS = acute coronary syndrome; C = clopidogrel; CV = cardiovascular; CVA = cerebral vascular accident; DAPT = dual antiplatelet therapy; DT = dual therapy; MACE = major adverse cardiovascular event; MI = myocardial infarction; OAC = oral anticoagulation; PCI = percutaneous coronary intervention; SAPT = single antiplatelet therapy; TT = triple therapy.