BioMed Research International / 2018 / Article / Tab 4

Review Article

Optimum Antithrombotic Therapy in Patients Requiring Long-Term Anticoagulation and Undergoing Percutaneous Coronary Intervention

Table 4

Meta-analyses comparing outcomes of dual with triple therapy.

Study/authorYearPatient populationNumber of patientsComparisonResults

Agarwal et al. [8]2017Patients with an indication for long-term anticoagulation undergoing PCI7,276TT versus DT(1) Less major bleeding with OAC + SAPT
(2) Comparable outcomes between OAC + SAPT and TT for MACE, MI, stent thrombosis, CV mortality

Liu et al. [46]2016Patients with indication for OAC and undergoing PCI or medically managed ACS22,842Network meta-analysis of TT, OAC + C, OAC + A, DAPT(1) OAC + C had the lowest rate of MACE, CVA, MI, all-cause mortality, and major bleeding

Barbieri et al. [47]2016Patients undergoing PCI that required long-term OAC21,716TT versus DT(1) As compared to DT, the use of TT was associated with significant reduction in overall mortality, recurrent MI, and ischemic stroke
(2) Patients with TT were found to have a higher incidence of bleeding

D’Ascenzo et al. [48]2015Patients with indication for OAC and undergoing PCI or medically managed ACS7,182TT versus DAPT, TT versus OAC + C(1) Major bleeding: DAPT and OAC + C both had less incidence as compared to TT
(2) MACE: no benefit of TT over OAC + C or DAPT

Gao et al. [49]2015Patients taking OAC with coronary stent implantation9,185TT versus OAC + C(1) Lower incidence of MACE with OAC + C
(2) Comparable outcomes between OAC + C and TT for all-cause mortality, MI, ST, ischemic thrombosis, and major and minor bleeding

ACS = acute coronary syndrome; C = clopidogrel; CV = cardiovascular; CVA = cerebral vascular accident; DAPT = dual antiplatelet therapy; DT = dual therapy; MACE = major adverse cardiovascular event; MI = myocardial infarction; OAC = oral anticoagulation; PCI = percutaneous coronary intervention; SAPT = single antiplatelet therapy; TT = triple therapy.