Table 7: Differently enriched pathways were obtained in SANFH-TCM versus healthy controls.

Pathway_accPathway_Name valueProtein in backgroundProteins in Diff ExpProtein list

hsa04978Mineral absorption0.03494922P02787, P13637,
hsa03320PPAR signaling pathway0.06834594P02656, P08519, Q6Q788, P06727,
hsa04062Chemokine signaling pathway0.08313663P10720, P02776, P02775,
hsa04261Adrenergic signaling in cardiomyocytes0.12618873P62158, P67936, P13637,
hsa04722Neurotrophin signaling pathway0.16178942P62158, P62258,
hsa04915Estrogen signaling pathway0.16178942P62158, P14625,
hsa04260Cardiac muscle contraction0.16178942P67936, P13637,
hsa04114Oocyte meiosis0.1753983P62158, P62258, Q8NDV3,
hsa00410beta-Alanine metabolism0.1879711Q96KN2,
hsa04964Proximal tubule bicarbonate reclamation0.1879711P13637,
hsa00340Histidine metabolism0.1879711Q96KN2,
hsa04070Phosphatidylinositol signaling system0.1879711P62158,
hsa04961Endocrine and other factor-regulated calcium reabsorption0.1879711P13637,
hsa04976Bile secretion0.1879711P13637,
hsa00860Porphyrin and chlorophyll metabolism0.1879711P00450,
hsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis0.1879711P80108,
hsa04960Aldosterone-regulated sodium reabsorption0.1879711P13637,
hsa00230Purine metabolism0.1879711P14618,
hsa04666Fc gamma R-mediated phagocytosis0.1879711P06396,

hsa02010ABC transporters0.1879711Q9NP78,
hsa04744Phototransduction0.1879711P62158,
hsa04611Platelet activation0.22891293P02675, P02679, P02671,
hsa04060Cytokine-cytokine receptor interaction0.22891293P10720, P02776, P02775,
hsa04918Thyroid hormone synthesis0.2376552P14625, P13637,
hsa04971Gastric acid secretion0.2376552P62158, P13637,
hsa04970Salivary secretion0.2376552P62158, P13637,
hsa05200Pathways in cancer0.31490762P02751, P14625,
hsa04910Insulin signaling pathway0.34099121P62158,
hsa04912GnRH signaling pathway0.34099121P62158,
hsa04911Insulin secretion0.34099121P13637,
hsa04270Vascular smooth muscle contraction0.34099121P62158,
hsa05214Glioma0.34099121P62158,
hsa04014Ras signaling pathway0.34099121P62158,
hsa04614Renin-angiotensin system0.34099121P01019,
hsa05222Small cell lung cancer0.34099121P02751,
hsa05031Amphetamine addiction0.34099121P62158,
hsa04750Inflammatory mediator regulation of TRP channels0.34099121P62158,
hsa04720Long-term potentiation0.34099121P62158,
hsa04973Carbohydrate digestion and absorption0.34099121P13637,
hsa04972Pancreatic secretion0.34099121P13637,
hsa05203Viral carcinogenesis0.342177113P14618, P06396, P62258,
hsa05152Tuberculosis0.39039472P18428, P62158,
hsa04110Cell cycle0.39039472P62258, Q8NDV3,
hsa03050Proteasome0.39039472P49721, O14818,
hsa05010Alzheimer’s disease0.39039472P62158, P02649,

hsa04740Olfactory transduction0.46548931P62158,
hsa04713Circadian entrainment0.46548931P62158,
hsa04728Dopaminergic synapse0.46548931P62158,
hsa04064NF-kappa B signaling pathway0.46548931P18428,
hsa04930Type II diabetes mellitus0.46548931P14618,
hsa04620Toll-like receptor signaling pathway0.46548931P18428,
hsa04916Melanogenesis0.46548931P62158,
hsa05100Bacterial invasion of epithelial cells0.46548931P02751,
hsa00620Pyruvate metabolism0.46548931P14618,
hsa04919Thyroid hormone signaling pathway0.46548931P13637,
hsa04621NOD-like receptor signaling pathway0.46548931P14625,
hsa00330Arginine and proline metabolism0.46548931Q96KN2,
hsa05215Prostate cancer0.46548931P14625,

Note. Italic font indicated the candidate protein.