Screening of Serum Protein Markers for Avascular Osteonecrosis of Femoral Head Differentially Expressed after Treatment with Yuanshi Shengmai Chenggu Tablets

Table 7

Differently enriched pathways were obtained in SANFH-TCM versus healthy controls.

Pathway_acc	Pathway_Name	value	Protein in background	Proteins in Diff Exp	Protein list
hsa04978	Mineral absorption	0.034949	2	2	P02787, P13637,
hsa03320	PPAR signaling pathway	0.068345	9	4	P02656, P08519, Q6Q788, P06727,
hsa04062	Chemokine signaling pathway	0.083136	6	3	P10720, P02776, P02775,
hsa04261	Adrenergic signaling in cardiomyocytes	0.126188	7	3	P62158, P67936, P13637,
hsa04722	Neurotrophin signaling pathway	0.161789	4	2	P62158, P62258,
hsa04915	Estrogen signaling pathway	0.161789	4	2	P62158, P14625,
hsa04260	Cardiac muscle contraction	0.161789	4	2	P67936, P13637,
hsa04114	Oocyte meiosis	0.17539	8	3	P62158, P62258, Q8NDV3,
hsa00410	beta-Alanine metabolism	0.18797	1	1	Q96KN2,
hsa04964	Proximal tubule bicarbonate reclamation	0.18797	1	1	P13637,
hsa00340	Histidine metabolism	0.18797	1	1	Q96KN2,
hsa04070	Phosphatidylinositol signaling system	0.18797	1	1	P62158,
hsa04961	Endocrine and other factor-regulated calcium reabsorption	0.18797	1	1	P13637,
hsa04976	Bile secretion	0.18797	1	1	P13637,
hsa00860	Porphyrin and chlorophyll metabolism	0.18797	1	1	P00450,
hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0.18797	1	1	P80108,
hsa04960	Aldosterone-regulated sodium reabsorption	0.18797	1	1	P13637,
hsa00230	Purine metabolism	0.18797	1	1	P14618,
hsa04666	Fc gamma R-mediated phagocytosis	0.18797	1	1	P06396,
hsa02010	ABC transporters	0.18797	1	1	Q9NP78,
hsa04744	Phototransduction	0.18797	1	1	P62158,
hsa04611	Platelet activation	0.228912	9	3	P02675, P02679, P02671,
hsa04060	Cytokine-cytokine receptor interaction	0.228912	9	3	P10720, P02776, P02775,
hsa04918	Thyroid hormone synthesis	0.23765	5	2	P14625, P13637,
hsa04971	Gastric acid secretion	0.23765	5	2	P62158, P13637,
hsa04970	Salivary secretion	0.23765	5	2	P62158, P13637,
hsa05200	Pathways in cancer	0.314907	6	2	P02751, P14625,
hsa04910	Insulin signaling pathway	0.340991	2	1	P62158,
hsa04912	GnRH signaling pathway	0.340991	2	1	P62158,
hsa04911	Insulin secretion	0.340991	2	1	P13637,
hsa04270	Vascular smooth muscle contraction	0.340991	2	1	P62158,
hsa05214	Glioma	0.340991	2	1	P62158,
hsa04014	Ras signaling pathway	0.340991	2	1	P62158,
hsa04614	Renin-angiotensin system	0.340991	2	1	P01019,
hsa05222	Small cell lung cancer	0.340991	2	1	P02751,
hsa05031	Amphetamine addiction	0.340991	2	1	P62158,
hsa04750	Inflammatory mediator regulation of TRP channels	0.340991	2	1	P62158,
hsa04720	Long-term potentiation	0.340991	2	1	P62158,
hsa04973	Carbohydrate digestion and absorption	0.340991	2	1	P13637,
hsa04972	Pancreatic secretion	0.340991	2	1	P13637,
hsa05203	Viral carcinogenesis	0.342177	11	3	P14618, P06396, P62258,
hsa05152	Tuberculosis	0.390394	7	2	P18428, P62158,
hsa04110	Cell cycle	0.390394	7	2	P62258, Q8NDV3,
hsa03050	Proteasome	0.390394	7	2	P49721, O14818,
hsa05010	Alzheimer’s disease	0.390394	7	2	P62158, P02649,
hsa04740	Olfactory transduction	0.465489	3	1	P62158,
hsa04713	Circadian entrainment	0.465489	3	1	P62158,
hsa04728	Dopaminergic synapse	0.465489	3	1	P62158,
hsa04064	NF-kappa B signaling pathway	0.465489	3	1	P18428,
hsa04930	Type II diabetes mellitus	0.465489	3	1	P14618,
hsa04620	Toll-like receptor signaling pathway	0.465489	3	1	P18428,
hsa04916	Melanogenesis	0.465489	3	1	P62158,
hsa05100	Bacterial invasion of epithelial cells	0.465489	3	1	P02751,
hsa00620	Pyruvate metabolism	0.465489	3	1	P14618,
hsa04919	Thyroid hormone signaling pathway	0.465489	3	1	P13637,
hsa04621	NOD-like receptor signaling pathway	0.465489	3	1	P14625,
hsa00330	Arginine and proline metabolism	0.465489	3	1	Q96KN2,
hsa05215	Prostate cancer	0.465489	3	1	P14625,

Note. Italic font indicated the candidate protein.