Review Article

Modeling Renal Disease “On the Fly”

Figure 1

Comparison of the human podocyte and the Drosophila nephrocyte slit diaphragms. Selected evolutionary conserved proteins are indicated. The same symbols indicate orthologous proteins between human and Drosophila. In the fly, Duf was found to directly interact with Pyd and Sns with podocin ortholog Mec-2 [6].