Review Article
A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China
Table 3
Meta-analysis of clinical manifestations of brucellosis by age category.
| Manifestation | Age category | All studies | Children | Adults | All ages | General | | % [95% CI] | | % [95% CI] | | % [95% CI] | | % [95% CI] |
| Fever | 10 | 92 ; | 17 | 99 ; | 41 | 83 [80; 87] | 68 | 87 [85; 90] | Fatigue | 7 | 68 ; | 14 | 64 ; | 34 | 62 [57; 67] | 55 | 63 [59; 67] | Chills | 3 | 26 ; | 5 | 53 ; 79] | 4 | 37 [33; 42] | 12 | 43 [33; 55] | Sweats | 8 | 60 ; | 16 | 57 [48; 68] | 39 | 54 [49; 59] | 63 | 55 [51; 60] | Arthralgia | 9 | 52 ; | 17 | 61 [52; 70] | 40 | 63 [59; 68] | 66 | 62 [58; 65] | Headache | 4 | 8 ; | 10 | 29 [19; 42] | 27 | 21 [18; 25] | 41 | 21 [18; 25] | Muscle pain | 2 | 31 ; | 5 | 76 [60; 95] | 20 | 53 [47; 59] | 27 | 56 [51; 62] | Nausea/vomiting | 6 | 27 ; | 8 | 26 [15; 45] | 17 | 25 [19; 34] | 31 | 26 [21; 33] | Rash | 3 | 13 ; | 3 | 7 [3; 19] | 9 | 5 [3; 11] | 15 | 7 [4; 11] | Weight loss | 0 | - | 4 | 26 [14; 47] | 5 | 32 [17; 61] | 9 | 29 [17; 48] | Skin petechia | 3 | 8 ; | 2 | 18 [10; 32] | 9 | 5 [3; 8] | 14 | 7 [4; 10] | Abdominal pain | 2 | 6 ; | 3 | 6 [3; 14] | 3 | 8 [4; 16] | 8 | 8 [5; 11] | Chest pain | 0 | - | 2 | 7 [3; 17] | 1 | 5 [3; 10] | 3 | 6 [3; 10] | Cough | 5 | 12 ; | 4 | 19 [12; 29] | 5 | 10 [8; 14] | 14 | 12 [10; 15] | Hepatomegaly | 7 | 28 ; | 7 | 23 [13; 40] | 23 | 13 [10; 17] | 37 | 16 [13; 20] | Splenomegaly | 7 | 35 ; | 10 | 29 [22; 39] | 23 | 21 [16; 27] | 40 | 24 [20; 29] | Lymphadenectasis | 7 | 38 ; | 7 | 32 [22; 48] | 27 | 16 [12; 21] | 41 | 19 [15; 25] | Hepatitis | 8 | 48 ; | 15 | 60 [52; 69] | 24 | 38 [30; 49] | 47 | 45 [38; 54] | Neurological | 4 | 8 ; | 3 | 8 [2; 36] | 14 | 4 [2; 9] | 21 | 5 [3; 10] | Cardiac | 3 | 19 ; | 2 | 5 [1; 19] | 12 | 9 [6; 14] | 17 | 9 [6; 16] | Hemophagocytic syndrome | 0 | - | 0 | - | 4 | 6 [2; 23] | 4 | 6 [2; 23] | Respiratory | 5 | 26 ; | 3 | 11 [6; 20] | 8 | 9 [4; 23] | 16 | 13 [7; 21] | Orchitis/ epididymitis | 1 | 67 ; | 7 | 6 [3; 12] | 34 | 9 [7; 12] | 42 | 9 [7; 12] | Osteoarthritis | 2 | 16 ; | 4 | 22 [9; 52] | 11 | 23 [17; 31] | 17 | 22 [17; 29] |
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