Synergistic Activity of Colistin/Fosfomycin Combination against Carbapenemase-Producing Klebsiella pneumoniae in an In Vitro Pharmacokinetic/Pharmacodynamic Model

Figure 2

(Left) time-kill curves with various clinically relevant dosage regimens of colistin (Col) and fosfomycin (Fos) alone and in combination at an inoculum of 10⁸ CFU/mL. (Right) PAPs at baseline and after 24 h of exposure to colistin monotherapy, colistin-fosfomycin combination therapy, or neither antibiotic (growth control). Fosfomycin monotherapy regimens were not included in colistin-PAP examination. (a) KP47 (colistin-susceptible, fosfomycin-susceptible); (b) KP79 (colistin-heteroresistant, fosfomycin-susceptible); (c) KP42 (colistin-heteroresistant, fosfomycin-resistant); (d) KP11 (colistin-heteroresistant, fosfomycin-resistant).

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