Expression of miR-652-3p and Effect on Apoptosis and Drug Sensitivity in Pediatric Acute Lymphoblastic Leukemia

Figure 3

Effects of overexpressing miR-652-3p in lymphoblastic leukemia cell lines. (a) The growth of cells was examined using the MTS assay after drug treatment for 24h. For the Reh cell line treated with cytarabine (Ara-C), the IC50 of agomir-Ctrl was 0.06129 μg/mL and the IC50 of agomir-652 was 0.03049 μg/mL. For the Reh cell line treated with vincristine (VCR), the IC50 of agomir-Ctrl was 0.07354 μg/mL and the IC50 of agomir-652 was 0.03736 μg/mL. For the RS 4:11 cell line treated with Ara-C, the IC50 of agomir-Ctrl was 2.074 μg/mL and the IC50 of agomir-652 was 0.1715 μg/mL (panel 3). For the RS 4:11 cell line treated with VCR, the IC50 of agomir-Ctrl was 3.665 μg/mL and the IC50 of agomir-652 was 0.3891 μg/mL. (b) Representative images of FACS analysis of apoptosis in the Reh (left) and RS4:11 (right) cell lines.

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