Molecular Analysis and Modeling of Hepatitis E Virus Helicase and Identification of Novel Inhibitors by Virtual Screening

<div>Binding interaction of the best selected compounds with the HEV-helicase active residues. The modeled protein (residues no. 1-232 corresponding to HEV-hel a.a. 963-1194) shows the interacting residues Gly13 (HEV-hel Gly975), Gly16 ((HEV-hel Gly978), Ser17 (HEV-hel Ser979), and Gly18 (HEV-hel Gly980) within the highly conserved Walker A motif.</div>

BioMed Research International

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Figure 5

Figure 5: Molecular Analysis and Modeling of Hepatitis E Virus Helicase and Identification of Novel Inhibitors by Virtual Screening 