Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway<i> Pseudomonas aeruginosa</i> Infection in Mice

<div>FT inhibits the secretion of<i> P. aeruginosa </i>T3SS effectors in the clinical isolates under the study. Expression of T3SS was induced by adding 5 mM of EGTA to culture media. FT was added in concentrations from 10 to 40 <i>μ</i>g/ml. ExoT and ExoY were evaluated by immunoblot with polyclonal antibodies against ExoТ and ExoY.</div>

BioMed Research International

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Figure 7

Figure 7: Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway<i> Pseudomonas aeruginosa</i> Infection in Mice 

Figure 7 | Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice 