Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway<i> Pseudomonas aeruginosa</i> Infection in Mice

<div>FT reduced<i> P. aeruginosa </i>cytotoxicity towards CHO cells. (a) ExoU expressing<i> P. aeruginosa </i>clinical isolates; (b) ExoS expressing<i> P. aeruginosa </i>clinical isolates. Dark bars, controls; white bars, 10 <i>μ</i>g/ml of FT; crossed bars, 20 <i>μ</i>g/ml; checkered bars, 40 <i>μ</i>g/ml of FT, P &lt; 0.05.</div>

BioMed Research International

fig8

Figure 8

Figure 8: Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway<i> Pseudomonas aeruginosa</i> Infection in Mice 

Figure 8 | Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice 