Antidepressant-Like Effects of Gyejibokryeong-hwan in a Mouse Model of Reserpine-Induced Depression

Figure 7

Effect of Gyejibokryeong-hwan (GBH) on hippocampal BDNF and p-CREB, as measured using immunofluorescence, in mice with reserpine-induced depression. Frozen hippocampal sections were analyzed based on immunofluorescence using (a) BDNF (green) and (b) p-CREB (green) antibodies. DAPI (blue) was used to visualize nuclei. Data are representative of three independent experiments and are presented as the mean ± standard deviation (SD) (one-way ANOVA; < 0.05, < 0.001 versus normal; p < 0.05, p < 0.01, p < 0.001 versus control). BDNF: brain-derived neurotrophic factor; p-CREB: phosphorylated cAMP response element-binding protein.