Gene Expression Patterns Analysis in the Supraspinatus Muscle after a Rotator Cuff Tear in a Mouse Model
Table 1
Summary of the rotator cuff tear-induced expression for genes belonging to 10 categories at (a) 1 and (b) 4 weeks.
(a)
Total
10 categories associated with muscle physiology
1 week
Total
Aging
Angio.
Apop.
Diff.
Migr.
Prolif.
ECM
Infl.
FA tr.
Atro
Total gene number
39,429
370
443
1,100
4,701
994
788
683
532
66
19
% of Total
100
0.94
1.12
2.79
11.92
2.52
2
1.73
1.35
0.17
0.05
Up significant (n)
8,662
127
174
378
1,422
386
262
264
249
10
3
% of Up significant
22
34.3
39.3
34.4
30.2
38.8
33.2
38.7
46.8
15.2
15.8
Down significant (n)
3,516
40
30
113
436
75
45
54
31
13
9
% of Down significant
8.9
10.8
6.8
10.3
9.3
7.5
5.7
7.9
5.8
19.7
47.4
Total significant (n)
12,178
184
203
525
1,867
463
300
267
278
23
11
% of Total significant
30.9
45.1
46
44.6
39.5
46.4
39
46.6
52.6
34.8
63.2
(b)
Total
10 categories associated with muscle physiology
4 weeks
Total
Aging
Angio.
Apop.
Diff.
Migr.
Prolif.
ECM
Infl.
FA tr.
Atro
Total gene number
39,429
370
443
1,100
4,701
994
788
683
532
66
19
% of Total
100
0.94
1.12
2.79
11.92
2.52
2
1.73
1.35
0.17
0.05
Up Significant (n)
1,233
21
20
52
203
59
35
31
46
2
1
% of Up Significant
3.1
5.7
4.5
4.7
4.3
5.9
4.4
4.5
8.6
3
5.3
Down Significant (n)
1,137
8
9
34
150
31
32
12
15
0
4
% of Down Significant
2.9
2.2
2
3.1
3.2
3.1
4.1
1.8
2.8
0
21.1
Total Significant (n)
2,370
29
29
86
353
90
67
43
61
2
5
% of Total Significant
6
7.8
6.5
7.8
7.5
9.1
8.5
6.3
11.5
3
26.3
Angio., angiogenesis; Apop., apoptosis; Diff., cell differentiation; Migr., cell migration; Prolif., cell proliferation; ECM, extracellular matrix; Infl., inflammation; FA tr., fatty acid transport; Atro., muscle atrophy. Up significant means the genes with the fold change of rotator cuff tear/control of more than 2 the raw values (log2) of more than 4. Down significant means the genes with the fold change of rotator cuff tear/control of less than 1/2 with the raw values (log2) of more than 4.
