Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma

Table 1

Differential expressed CYP450 genes between tumor and nontumor tissues from GSE14520 and GSE36376.

Genes	t	B		P value	Adjust P value	Common genes
GSE14520						CYP1A2; CYP2A6; CYP2C8; CYP2C9; CYP2E1; CYP3A4; CYP4A11
CYP1A2	25.7352762	49.901907	4.44705742	1.63E-22	7.31E-27
CYP2A6	7.9627779	12.348032	3.07188278	3.66E-08	7.66E-10
CYP2B6	15.7936233	33.005014	3.89306938	6.65E-16	5.37E-19
CYP2B7P	24.284837	180.032064	3.5900407	1.8E-81	1.25E-83
CYP2C8	6.4917335	7.665054	4.32698325	0.0000018	8.78E-08
CYP2C9	23.3715192	46.568366	3.36577273	1.63E-21	2.93E-25
CYP2E1	8.2816633	13.340866	4.73015789	0.000000016	2.81E-10
CYP3A4	7.9970664	12.45527	3.99461005	3.37E-08	6.87E-10
CYP4A11	8.8192119	14.989899	3.11363397	3.99E-09	5.29E-11
CYP4A22	8.6445676	14.457718	3.17968421	6.1E-09	9.06E-11
CYP39A1	10.5703094	20.114355	3.19955263	5.84E-11	2.94E-13
GSE36376
CYP1A2	30.5006424	240.408848	4.97	1.29E-106	6.05E-110
CYP2A6	15.0803249	83.643956	2.47	2.71E-40	1.3E-41
CYP2C8	17.410711	107.141675	3.05	2.5E-50	7.36E-52
CYP2C9	14.9361339	82.220342	2.36	1.1E-39	5.44E-41
CYP2E1	15.0716592	83.558278	3	2.95E-40	1.42E-41
CYP3A4	22.4720068	159.580681	3.91	1.3E-72	1.03E-74
CYP4A11	14.3069129	76.061125	2.06	4.62E-37	2.65E-38
CYP8B1	12.9803487	63.40673	2.18	1.18E-31	8.9E-33