Global, Survival, and Apoptotic Transcriptome during Mouse and Human Early Embryonic Development

Figure 1

Number of genes that are differentially expressed during early human and mouse embryo development (a) and the top five canonical pathways associated with each stage in both species (b). Y-axis represents canonical pathways with stacked bar associated for each pathway with the number of downregulated (green color) and upregulated (red color) genes indicated in bold italic. The total number and percentage of downregulated and upregulated genes associated with each specific canonical pathway were indicated in bold to the right of each bar and to the top of the X-axis, respectively. At the bottom of the X-axis, the logarithmic p-value of each canonical pathway was indicated (orange). MII, metaphase II oocytes; EGA, embryonic genome activation stage; BL, blastocytes; EIF2, EIF2 signalling; Ubiq, protein ubiquitination pathway; eIF4/p70S6K, regulation of eIF4 and p70S6K signalling; Cancer, hereditary breast cancer signalling; mTOR, mTOR signalling; OxPhos, oxidative phosphorylation; Mito, mitochondrial dysfunction; Sirtuin, sirtuin signalling pathway; PLK, mitotic roles of polo-like kinase; Cell Cycle, cell cycle control of chromosomal replication; Junction, epithelial adherens junction signalling; Checkpoint, cell cycle: G2/M DNA damage checkpoint regulation; UPR, unfolded protein response.

(a)

(b)