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BioMed Research International
Volume 2018, Article ID 5972064, 8 pages
Research Article

Efficacy of Statin Therapy Related to Baseline Renal Function in Patients with Rheumatic Heart Disease Undergoing Cardiac Surgery

1Department of Cardio-Vascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
2Department of Gastroenterology, Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China
3The Biobank of Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
4Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China

Correspondence should be addressed to Songran Yang; moc.621@nargnosgnay and Ping Hua; moc.anis@88gnipauh

Received 22 September 2017; Revised 31 December 2017; Accepted 22 February 2018; Published 15 April 2018

Academic Editor: Jozef Zustin

Copyright © 2018 Rongjun Zou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Renal impairment increases the risk of cardiovascular events and perioperative complications in patients with heart valve disease. This study aimed to determine the perioperative benefit of statin treatment related to baseline renal function in patients with rheumatic heart disease (RHD) who had cardiac surgery. Methods and Results. We performed a retrospective study on 136 patients with RHD who underwent valve replacement surgery. The mean age of the patients was 56.2 years, 59.6% were female, 8.8% patients had diabetes mellitus, and 27.2% of patients had hypertension. Overall, 3 patients died, 2 underwent reoperation, and 25 underwent thoracentesis during the study period. For patients with renal impairment, there was a higher risk of thoracic puncture (odds ratio [OR]: 3.33; 95% confidence interval [CI]: 1.36, 8.11; ) and a longer time of drainage (difference in means: 1; 95% CI: 0.88, 1.12; ), intensive care unit (ICU) stay (difference in means: 0.2; 95% CI: 0.17, 0.23; ), and hospital stay (difference in means: 6.6; 95% CI: 6.15, 7.05; ) compared with normal renal function. Furthermore, statins were associated with a reduction in drainage time (difference in means: −1.50; 95% CI: −1.86, −1.14; ), ICU stay (difference in means: −0.30; 95% CI: −0.40, −0.20; ), and hospital stay (difference in means: −5.40; 95% CI: −6.57, −4.23; ) in patients with renal impairment (interaction, for all), but not in those with normal renal function. Conclusion. Statins have a greater clinical benefit in perioperative cardiac surgery with renal impairment. Statins are associated with a comparatively lower risk of thoracic puncture, as well as a reduced trend toward a reduction in drainage time, ICU stay, and hospital stay.