Peptide Extract from Olivancillaria hiatula Exhibits Broad-Spectrum Antibacterial Activity
Table 4
Co-modulation studies: MICs of Cefotaxime plus 20 μg/mL of peptide extract.
Organism
MIC (μg/mL)
Cef
Cef + P
MF
Change in MIC (%)
E. coli (-)
31.25
1.95
16
93.75R
K. pneumonia (-)
31.25
3.91
8
87.50R
S. paratyphi (-)
62.5
3.91
16
93.75R
P. mirabilis (-)
31.25
0.24
130
99.22R
N. gonorrhea (-)
31.25
62.50
0.5
100.00I
V. cholera (-)
62.5
1.19 ×
525210
99.99R
P. aeruginosa (-)
31.25
1.19×
262605
100.00R
S. aureus (+)
250.00
>250.00
<1
100.00I
E. faecalis (+)
31.25
1.95
16
93.75R
MIC experiments were replicated thrice; change in MIC computed using equation (2). MF: modulation factor, Cef: cefotaxime, P: peptide extract, and R: reduction in MIC, I: increase in MIC.