Peptide Extract from Olivancillaria hiatula Exhibits Broad-Spectrum Antibacterial Activity

Table 4

Co-modulation studies: MICs of Cefotaxime plus 20 μg/mL of peptide extract.

Organism	MIC (μg/mL)
	Cef	Cef + P	MF	Change in MIC (%)
E. coli (-)	31.25	1.95	16	93.75^R
K. pneumonia (-)	31.25	3.91	8	87.50^R
S. paratyphi (-)	62.5	3.91	16	93.75^R
P. mirabilis (-)	31.25	0.24	130	99.22^R
N. gonorrhea (-)	31.25	62.50	0.5	100.00^I
V. cholera (-)	62.5	1.19 ×	525210	99.99^R
P. aeruginosa (-)	31.25	1.19×	262605	100.00^R
S. aureus (+)	250.00	>250.00	<1	100.00^I
E. faecalis (+)	31.25	1.95	16	93.75^R

MIC experiments were replicated thrice; change in MIC computed using equation (2).
MF: modulation factor, Cef: cefotaxime, P: peptide extract, and R: reduction in MIC, I: increase in MIC.