Manifestations and Outcomes of Patients with Parkinson’s Disease and Serious Infection in the Emergency Department

Table 4

Comparison of survivors and nonsurvivors of septic Parkinson’s disease within 28 days of admission.

Variable	Survivors	Nonsurvivors	P value
	(n = 1,114)	(n = 86)
Age (years), mean ± SD	77.1 ± 8.9	79.6 ± 7.0	0.01
Sex, male, n (%)	589 (52.9%)	34 (39.5%)	0.01
Vital signs at ED, mean ± SD
Body temperature (°C), mean ± SD	37.5 ± 1.2	37.3 ± 1.4	0.167
Heart rate (beats per minute), mean ± SD	98.5 ± 20.9	102.9 ± 32.1	0.216
Systolic blood pressure (mmHg), mean ± SD	139.9 ± 34.0	125.0 ± 41.8	0.00
Diastolic blood pressure (mmHg), mean ± SD	80.6 ± 33.8	71.0 ± 24.4	0.01
Respiratory rate (breaths per minute), mean ± SD	20.3 ± 3.3	20.7 ± 6.1	0.653
Major comorbidities, n (%)
Liver cirrhosis	28 (2.5%)	5 (5.8%)	0.081
Hypertension	568 (51.0%)	37 (43.0%)	0.155
Diabetes mellitus	421 (37.8%)	17 (25.6%)	0.02
Renal insufficiency	96 (8.6%)	19 (22.1%)	<0.00
Congestive heart failure	61 (5.5%)	10 (11.6%)	0.02
Malignancy	98 (8.8%)	16 (18.6%)	0.00
Hematologic disorder	7 (0.6%)	2 (3.0%)	0.086
Autoimmune disease	7 (0.6%)	0 (0%)	1.000
Major source of infection, n (%)
Respiratory tract	531 (47.7%)	63 (73.3%)	<0.00
Urinary tract	563 (50.5%)	20 (23.3%)	<0.00
Soft tissue infection	82 (7.4%)	5 (5.8%)	0.828
Meningitis	4 (0.4%)	1 (1.2%)	0.265
Intra-abdomen infection	17 (1.5%)	0 (0%)	0.627
Biliary tract infection	27 (2.4%)	2 (2.3%)	1.000
Other	126 (11.3%)	14 (16.3%)	0.167
Bacteremia, n (%)	146 (13.1%)	15 (17.4%)	0.256
ICU admission, n (%)	100 (9.0%)	24 (27.9%)	<0.00
Septic shock within 72 hours, n (%)	41 (3.7%)	19 (22.1%)	<0.00
Respiratory failure within 72 hours, n (%)	94 (8.4%)	28 (32.6%)	<0.00

SD: standard deviation; ED: emergency department; ICU: intensive care unit
< 0.05