Mammographic Breast Density and Breast Cancer Molecular Subtypes: The Kenyan-African Aspect

Table 2

Relationships between patient and clinical characteristics of women with breast cancer and mammographic density measurements (unadjusted and adjusted analysis).

Clinical characteristic	n	(%)	Percent density (%)						Absolute dense area						Nondense area
			Unadjusted			Adjusted			Unadjusted			Adjusted			Unadjusted			Adjusted
			Mean	95% CI		Mean	95% CI		Mean	95% CI		Mean	95% CI		Mean	95% CI		Mean	95% CI
Age
<50 years	48	39	31.9	28.6	35.2	31.8	28.4	35.2	106.2	91.5	120.9	110.1	95.0	125.3	223.8	189.3	258.4	232.5	200.3	264.8
≥50 years	75	61	19.9	17.8	22.0	19.8	17.7	21.9	70.7	61.1	80.2	72.1	62.4	81.7	301.6	269.5	333.7	306.9	277.7	336.0
P value			<0.01			<0.01			<0.01			<0.01			0.03			0.02
Menopausal status
Pre	42	34	30.7	27.1	34.2	24.0	19.9	28.0	96.2	80.9	111.5	69.1	52.8	85.4	214.1	178.2	250.1	228.8	184.8	272.8
Post	81	66	21.2	19.0	23.3	24.1	21.6	26.7	77.5	67.6	87.4	94.7	82.7	106.7	301.4	270.6	332.1	303.1	271.3	334.9
P value			<0.01			0.96			0.15			0.13			0.01			0.10
BMI category
Lean	18	15	27.0	21.7	32.2	26.2	21.4	31.0	50.8	34.3	67.3	49.1	33.3	64.8	133.8	95.1	172.5	137.0	98.6	175.5
Overweight	54	44	25.4	22.5	28.4	24.9	22.2	27.6	86.1	73.6	98.6	84.5	72.5	96.5	261.9	230.4	293.3	265.1	234.1	296.2
Obese	43	35	21.3	18.3	24.3	22.2	19.3	25.1	102.9	87.6	118.2	106.1	91.0	121.2	376.0	333.8	418.2	368.8	327.6	409.9
P value for trend			0.29			0.52			0.01			<0.01			<0.01			<0.01
Diagnosis
Invasive ductal	105	85	24.6	22.5	26.6	24.1	22.1	26.0	80.7	71.8	89.6	82.8	74.3	91.4	256.7	231.5	281.9	268.0	245.2	290.8
Other	18	15	22.6	17.7	27.4	23.9	18.9	28.9	101.8	77.7	125.9	106.2	81.2	131.2	353.4	282.1	424.7	342.3	275.8	408.8
P value			0.59			0.94			0.25			0.21			0.07			0.14
Tumor size
<3 cm	53	43	22.7	19.9	25.6	22.1	19.4	24.7	72.5	60.8	84.1	74.4	63.3	85.5	254.5	218.6	290.4	271.3	238.5	303.1
≥3 cm	58	47	24.8	22.0	27.7	24.9	22.2	27.7	91.5	79.0	104.1	93.2	80.9	105.5	289.9	253.3	326.5	283.6	255.6	321.6
P value			0.47			0.30			0.13			0.12			0.34			0.60
Tumor grade
Grade 1	14	11	31.4	25.0	37.9	30.5	24.6	36.4	107.3	78.9	135.7	118.7	91.1	146.4	253.2	184.8	321.5	295.5	230.5	360.4
Grade 2	57	46	22.8	20.1	25.6	22.9	20.3	25.5	82.0	69.7	94.3	88.2	76.1	100.3	280.3	244.5	316.1	294.4	261.5	327.4
Grade 3	49	40	24.8	21.7	27.8	24.1	21.3	27.0	78.8	65.8	91.9	74.2	62.2	86.1	247.5	211.2	283.8	242.0	209.9	274.2
P value for trend			0.21			0.25			0.43			0.10			0.65			0.26
BMI: body mass index
Nodal status
Negative	49	40	24.8	21.6	27.9	24.1	21.1	27.0	92.1	78.2	106.0	91.6	78.3	104.9	297.9	257.8	337.9	298.4	263.1	333.8
Positive	60	49	22.9	20.2	25.6	22.9	20.3	25.4	76.1	64.7	87.5	79.4	68.5	90.3	257.2	223.5	290.8	270.3	240.7	299.8
P value			0.53			0.67			0.22			0.33			0.28			0.40

for age and BMI. BMI: body mass index.