Effects of Vitamin D Restricted Diet Administered during Perinatal and Postnatal Periods on the Penis of Wistar Rats
Table 2
Parameters from offspring at 4 months of age.
Parameters
SC/SC
VitD/VitD
Food intake (g/animal/dia)
19.09 ± 3.98
18.91 ± 4.18
ns
Energy intake (kJ/animal/dia)
309.80 ± 62.46
306.30 ± 64.69
ns
Systolic blood pressure (mmHg)
164.00 ± 11.11
189.10 ± 8.08
<0.0001
Glucose (mmol/L)
6.04 ± 2.08
11.26 ± 4.15
0.0096
Insulin (µUI/L)
21.50 ± 8.75
33.76 ± 3.52
0.0072
25 OHD3 (ng/ml)
73.71 ± 8.86
28.74 ± 0.20
<0.0001
Penile parameters
SC/SC
VitD/VitD
Morphometry
A (mm2)
6.51 ± 1.35
6.15 ± 1.02
0.0083
CC with TA (mm2)
4.51 ± 0.95
4.19 ± 0.69
0.0007
CC without TA (mm2)
2.17 ± 0.54
2.05 ± 0.32
0.0133
TA (mm2)
2.34 ± 0.45
2.13 ± 0.45
0.0001
CE (mm2)
0.97 ± 0.12
1.02 ± 0.13
0.0015
Percentage in corpus cavernosum
Connective tissue (%)
62.58 ± 13.81
68.54 ± 12.31
<0.0001
Smooth muscle (%)
8.55 ± 3.49
10.70 ± 3.70
<0.0001
Sinusoidal space (%)
22.24 ± 16.57
17.45 ± 8.33
0.0002
Elastic fibers (%)
5.09 ± 1.72
4.33 ± 1.93
0.0009
PCNA (cells/mm2)
0.0161
Percentage in corpus spongiosum
Connective tissue (%)
59.04 ± 15.40
68.62 ± 14.79
<0.0001
Smooth muscle (%)
4.85 ± 2.61
5.87 ± 3.30
0.0074
Elastic fibers (%)
19.40 ± 9.42
19.73 ± 8.10
ns
Elastic fibers in tunica albuginea (%)
24.59 ± 6.79
21.00 ± 6.48
<0.0001
Data are presented as mean ± standard deviation and the differences were tested with an unpaired test (). A, penile cross sectional area; CC with TA, corpus cavernosum area with tunica albuginea; CC without TA, corpus cavernosum area without tunica albuginea; TA, tunica albuginea; CE, corpus spongiosum; PCNA, proliferating cell nuclear antigen; ns, not significant.
