Retrospective Analysis of Endocrine Dysfunctions in a Population of Adult Polytransfused Patients: Correlation of GH-IGF1 Axis Alteration with Cardiac Performance

Table 2

Anthropometric, laboratory, and echocardiograph data of 21/31 patients who underwent GHRH testing divided according to heart dysfunction (HD).

PARAMETER	HD (n=9)	Non-HD (n=12)	P
Mean age (years)	35.5 ± 10.4	32.6±12	NS
(Range)	(23-49)	(9-41)
BMI (Kg/m^2)	22.4±2.5	22±3.04	NS
Ferritin levels (μg/L)	1326±1175	1304.6±1048.9	NS
IGF-1 (μg/L)	53±30	122±91	0.04
Mean GH peak (μg/L)	8.00±5.64	32.1±21	0.003
HCV positivity (%)	100	77	NS
Number of Endocrinopathies	3.7 ± 1.2	2.0 ± 1.2	0.006
HH	6	8	NS
DM/IGT	4	2	NS
Hypot	3	2	NS
Hypopar	2	0	NS
GHD	9	3	0.001
Osteop	9	8	NS
LVDD (mm)	52.5±4.7	47.6±4.8	0.03
LAD (mm)	42.25±2	37.7±5.7	0.03
E/E' ratio	11.32±1.6	9.3±1.27	0.04
LVEF (%)	57.75±2.49	60.3±5.53	0.16
E/A ratio	1.92±0.2	1.98±0.35	0.7

HD: heart dysfunction; non-HD: no heart dysfunction; LVDD: left ventricular diastolic diameter; LAD: left atrial diameter; E/E’: transmitral to mitral annular early diastolic velocity ratio; LVEF: left ventricular ejection fraction; E/A: ratio of transmitral early to late. Hypot: primary hypothyroidism; GHD: severe+mild GH deficiency; DM/IGT: diabetes mellitus or impaired glucose tolerance; Hypoparat: primary hypoparathyroidism; HH: hypogonadotropic hypogonadism; Osteop: osteoporosis or osteopenia. Data are shown as mean ± SD.