Natural Compound Oridonin Inhibits Endotoxin-Induced Inflammatory Response of Activated Hepatic Stellate Cells

Figure 4

Oridonin and PES-CI synergistically inhibit LPS-induced proinflammatory cytokines. LX-2 cells were pretreated with oridonin (2.5 μM), or PES-CI (2.5 μM) or combination of two agents for 1 h, then stimulated with LPS (1 μg/mL) for 24 h. Cell culture medium was collected for ELISA of IL-6 (a) and MCP-1 (b). Data are representative of 3 independent experiments.

(a)

(b)