Liposomal Incorporation to Improve Dissolution and Stability of Rosmarinic Acid and Carvacrol Extracted from Oregano (O. onites L.)

Table 2

Characteristics of various empty and Oregano extract-loaded liposomes.

Formulation	Mean Size (nm)	Zeta potential (mV)	PDI (polydispersity index)
L90	1176±148.6++	1.53± 0.14++	0.23±0.02⧫
L1	107.4±0.45	-35.7± 1.08	0.25±0.04 ⧫
L2	97.48±0.23	-40.5± 2.08	0.34±0.02⧫
L3	43.9±0.45	-49.5±4.08	0.54±0.02⧫
E	103.7±23.02	-23.7±7.47	0.65±0.03
LE90	2660±17.02	12.45±7.47 ++	0.33±0.06 ⧫
LE1	234.3±35.56 +	-30.9±9.12	0.35±0.02 ⧫
LE2	266.1±17.02 +	-28.5±0.47 +	0.47±0.06
LE3	634.3±35.56 +	-25.9±2.12 +	0.57±0.02 ⧫

RA: rosmarinic acid.
CA: carvacrol.
+ p ≤ 0.05 vs L2, L1, and L3.
++ p ≤ 0.05 vs L1, L3, L2, E, LE1, LE2, and LE3.
⧫ p ≤ 0.05 vs E.