De Novo Endotoxin-Induced Production of Antibodies against the Bile Salt Export Pump Associated with Bacterial Infection following Major Hepatectomy

Figure 6

Immunofluorescence analysis of newly formed antibodies against bile salt export pump (BSEP) protein and IgM antibodies. Positive staining of both IgM and BSEP was detected in certain areas of the liver tissue of mice that had undergone 70% hepatectomy plus high-dose lipopolysaccharide (LPS) treatment. However, weak or barely detectable double positive for IgM and BSEP was noted in the liver tissue of mice that had not undergone hepatectomy or in those that had undergone 70% hepatectomy without LPS treatment.