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BioMed Research International
Volume 2018, Article ID 6215916, 10 pages
https://doi.org/10.1155/2018/6215916
Review Article

An Intervention Target for Myocardial Fibrosis: Autophagy

1Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
2Department of Cardiovascular Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
3Department of Geriatric Medicine, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

Correspondence should be addressed to Shichao Lv; moc.qq@720272273 and Junping Zhang; moc.361@mcthzjt

Received 19 November 2017; Revised 7 February 2018; Accepted 19 February 2018; Published 2 April 2018

Academic Editor: Michael Gotzmann

Copyright © 2018 Chunmiao Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myocardial fibrosis (MF) is the result of metabolic imbalance of collagen synthesis and metabolism, which is widespread in various cardiovascular diseases. Autophagy is a lysosomal degradation pathway which is highly conserved. In recent years, research on autophagy has been increasing and the researchers have also become cumulatively aware of the specified association between autophagy and MF. This review highlights the role of autophagy in MF and the potential effects through the administration of medicine.