A Comparative In Vivo Study on Three Treatment Approaches to Applying Topical Botulinum Toxin A for Crow’s Feet

Table 4

Comparison of adverse events after treatment ().

Group	Pain score	erythema and edema score
intramuscular injections
intradermal Microdroplet
nanomicroneedles
value	19.272	4.772
value	<0.05	<0.05

Note: compared with baseline; compared with intramuscular injections group at the same time point; compared with intradermal Microdroplet group at the same time point; compared with nanomicroneedle group at the same time point.