A Comparative In Vivo Study on Three Treatment Approaches to Applying Topical Botulinum Toxin A for Crow’s Feet

Table 5

Comparison of the skin elasticity before and after treatment ().

Group	Baseline	1 week	4 weeks	12 weeks
intramuscular injections
intradermal microdroplet
nanomicroneedles
value	1.891	2.28	10.796	33.558
value	>0.05	>0.05	<0.05	<0.05

Note: compared with baseline; compared with intramuscular injections group at the same time point; compared with intradermal microdroplet group at the same time point; compared with nanomicroneedle group at the same time point.