A Comparative In Vivo Study on Three Treatment Approaches to Applying Topical Botulinum Toxin A for Crow’s Feet

Table 7

Comparison of the skin collagen I content before and after treatment ().

Group	Baseline	1 week	4 weeks	12 weeks
intramuscular injections
intradermal microdroplet
nanomicroneedles
value	2.068	1.873	5.205	26.211
value	>0.05	>0.05	<0.05	<0.05

Note: compared with baseline; compared with intramuscular injections group at the same time point; compared with intradermal microdroplet group at the same time point; compared with nanomicroneedle group at the same time point.