Rs4612666 Polymorphism of the NLRP3 Gene Is Associated with the Occurrence of Large Artery Atherosclerotic Ischemic Strokes and Microembolic Signals

Table 3

Genotype and allelic frequencies of NLRP3 SNPs in LAA patients and control subjects.

SNP site	LAA group (%)	Control group (%)	value	Adjusted OR	95% CI
rs4612666
genotype
CC	63 (21.5%)	93 (35.1%)	-	1
CT	163 (55.6%)	129 (48.7%)	0.090	1.531	0.935–2.505
TT	67 (22.9%)	43 (16.2%)	0.001	3.021	1.593–5.731
allele
C	289 (49.3%)	315 (59.4%)	-	1
T	297 (50.7%)	215 (40.6%)	0.001	1.506	1.188–1.909
rs10754558
genotype
CC	73 (24.9%)	71 (26.8%)	-	1
CG	154 (52.6%)	131 (49.4%)	0.650	1.127	0.672–1.889
GG	66 (22.5%)	63 (23.8%)	0.538	1.184	0.648–2.163
Allele
C	300 (51.2%)	273 (51.5%)	-	1
G	286 (48.8)	258 (48.5%)	0.916	1.013	0.801–1.281
rs7512998
genotype
CC	2 (0.7%)	3 (1.1%)	-	1
CT	45 (15.4%)	56 (21.1%)	0.492	2.275	0.218–23.768
TT	246 (84.0%)	206 (77.7%)	0.278	3.584	0.358–35.896
allele
C	49 (8.4%)	62 (11.7%)	-	1
T	537 (91.6%)	468 (88.3%)	0.063	1.452	0.978–2.154