Research Article

Revealing the Amylase Interactome in Whole Saliva Using Proteomic Approaches

Table 3

Distribution of proteins identified to interact with salivary amylase forming complex based on their biological functions.

Biological functionAccession number Protein name

Defense response to bacterium, virus, and fungus
Q9HC84Mucin-5B
B4E1M1cDNA FLJ60391, highly similar to lactoperoxidase
P05109Protein S100-A8
Q96DR5BPI fold-containing family A member 2
Q8N4F0BPI fold-containing family B member 2
Q9UGM3Deleted in malignant brain tumors 1 protein
P01876Ig alpha-1 chain C region
P01834Ig kappa chain C region
P01877Ig alpha-2 chain C region
B7Z759cDNA FLJ61672, highly similar to proteoglycan-4 (fragment)
Q8TAX7Mucin-7
B7ZAL5cDNA, FLJ79229, highly similar to lactotransferrin
B4DI70cDNA FLJ53509, highly similar to galectin-3-binding protein

Neutralization of chemical aggression
P04080Cystatin-B
P01037Cystatin-SN
P23280Carbonic anhydrase VI
P01036Cystatin-S
P09228Cystatin-SA
A8K2U0alpha-2-Macroglobulin-like protein 1
B4E3A8cDNA FLJ53963, highly similar to leukocyte elastase inhibitor
P04040Catalase
A7Y9J9Mucin 5AC, oligomeric mucus/gel-forming

Immune response and regulation of inflammation
P05109Protein S100-A8
P12273Prolactin-inducible protein
P01834Ig kappa chain C region
B2R4M6Protein S100
P01024Complement C3
P80188Neutrophil gelatinase-associated lipocalin
P01877Ig alpha-2 chain C region
A0A075B6K9Ig lambda-2 chain C regions (fragment)
B7Z747cDNA FLJ51120, highly similar to matrix metalloproteinase-9
Q6PJF2IGK@ protein

Mucosa protection and wound healing
B5ME49Mucin-16
P01833Polymeric immunoglobulin receptor
P35908Keratin, type II cytoskeletal 2 epidermal
P25311Zinc-alpha-2-glycoprotein
Q07869Peroxisome proliferator-activated receptor alpha
Q9UPN3Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
A7Y9J9Mucin 5AC, oligomeric mucus/gel-forming
Q8TAX7Mucin-7
P02647Apolipoprotein A-I
Q9UPN3Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Biological functions not directly related to host protection or unknown
G3CIG0MUC19 variant 12
A0A0C4DGN4Zymogen granule protein 16 homolog B
A0A024R9Y3HECT, UBA, and WWE domain containing 1, isoform CRA_a
E7ETD6Nucleosome-remodeling factor subunit BPTF
P06733alpha-Enolase
A7E2D6NAV2 protein
H7BY35Ryanodine receptor 2
Q6P5S2Protein LEG1 homolog
F8WA11CLIP-associating protein 1
P02533Keratin, type I cytoskeletal 14
B2R825alpha-1,4-Glucan phosphorylase
B4DVQ0cDNA FLJ58286, highly similar to actin, cytoplasmic 2
Q0QET7Glyceraldehyde-3-phosphate dehydrogenase (fragment)
J3QLC9Haptoglobin (fragment)
B7Z565cDNA FLJ54739, highly similar to alpha-actinin-1
C0JYZ2Titin
C8C504beta-Globin
H6VRF8Keratin 1
P13645Keratin, type I cytoskeletal 10
B1APF8cAMP-dependent protein kinase catalytic subunit beta (fragment)
F6KPG5Albumin (fragment)
E9PKG6Nucleobindin-2
Q9Y6V0Protein piccolo
P10599Thioredoxin
O95661GTP-binding protein Di-Ras3
B4E1T1cDNA FLJ54081, highly similar to keratin, type II cytoskeletal 5
A0A087WWT3Serum albumin
A8K739cDNA FLJ77339
P35527Keratin, type I cytoskeletal 9

Proteins involved in more than one process related to host protection.