Effects of Plasma Albumin on the Pharmacokinetics of Esomeprazole in ICU Patients
Table 2
Pharmacokinetic parameters of esomeprazole.
LPAG (26.29 ±3.55, n=19)
HPAG (34.82 ±3.05, n=13)
P
mean (s.d.), ug/mLh
6.93 (2.30)
6.42 (2.46)
0.54
mean (s.d.), ug/mLh
8.77 (3.70)
7.13 (3.91)
0.20
mean (s.d.), h
3.14 (0.63)
2.91 (0.75)
0.34
mean (s.d.), h
5.39 (2.16)
3.80 (1.42)
0.03
mean (s.d.), h
3.84 (1.54)
2.57 (0.99)
0.01
V
mean (s.d.), L
27.43 (7.48)
22.17 (6.02)
0.04
CL
mean (s.d.), L/h
5.58 (2.33)
6.85 (3.46)
0.21
mean (s.d.), ug/mL
2.31 (0.50)
2.80 (0.88)
0.04
AUC, area under curve; MRT, mean retention time of the drug in the organism; , half-life; CL, clearance; V, volume of drug distribution; , maximum drug concentration.
