Effect of Genetic and Laboratory Findings on Clinical Course of Antisynthetase Syndrome in a Hungarian Cohort

Table 2

Detailed comparison of anti-Jo-1+/anti-SSA+ and anti-Jo-1+/anti-SSA-patients.

	SSA positive patients		SSA negative patients		p
Demographic data
Number of patients:	17		32		-
Male/female:	1/16		6/26		0.397
Average age at disease onset ± SD (youngest-oldest):	36.12±11.08; (21-58)		47.22±12.87; (18-70)		0.004
Laboratory parameters
Average CK at diagnosis (U/l) ± SD:	3484.87±3549.27		2754.14±2878.91		0.465
Average LDH at diagnosis (U/l) ± SD:	871.33±491.29		949.64±707.46		0.705
Average CRP at diagnosis (mg/l) ± SD:	24.76±22.21		21.18±22.35		0.623
Average ESR at diagnosis (mm/h) ± SD:	26.94±19.34		22.81±13.98		0.394
Clinical symptoms
Myositis:	17	100%	32	100%	1
Interstitial lung disease:	9	53%	26	81%	0.039
Arthritis:	15	88%	28	88%	1
Raynaud’s phenomenon:	13	76%	19	59%	0.231
Dysphagia:	2	12%	4	13%	1
Fever:	10	59%	11	34%	1
Skin lesions (all):	9	53%	18	56%	1
there from:
Mechanic’s hand:	6	35%	10	31%	0.774
Gottron-papule:	2	12%	4	13%	1
Gottron-sign:	2	12%	4	13%	1
Scarf –sign:	1	6%	1	3%	1
V-sign:	2	12%	2	6%	0.607
Heliotrope rash:	0	0	3	9%	0.542
Periorbital oedema:	1	6%	2	6%	1
Alopecia:	1	6%	2	6%	1
Vasculitis-like skin lesion:	3	18%	3	9%	0.405
Livedo reticularis:	3	18%	1	3%	0.114
Skin erosion:	3	18%	0	0	0.037
Teleangiectasia:	1	6%	5	16%	0.65
Subcutaneous calcinosis:	1	6%	2	6%	1
Therapy
Maintenance dose of steroid (mg) ± SD:	9.53±12.56		3.47±3.95		0.031

SSA: Sjögren’s-syndrome-related antigen A; SD: standard deviation; CK: creatine kinase; LDH: lactate dehydrogenase; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate.